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  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STW 07

    Refining the modeling assumptions to understand the population health impact after introducing a reduced-risk product into a market

    BAKER G.
    Philip Morris Products S.A., Lausanne, Switzerland
    The Population Health Impact Model (PHIM) was developed prior to marketing our reduced risk product (RRP)*, to help assess and understand the potential impact of marketing such products on population health within specific countries. The PHIM uses...
  2. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 022 (also presented at CORESTA SSPT2019)

    A seven-month systems toxicology inhalation study in C57BL/6 mice demonstrates reduced pulmonary inflammation and emphysema following smoking cessation or switching to e-vapor aerosol exposures

    KUMAR A.(1); KOGEL U.(2); TALIKKA M.(2); HOENG J.(2); PEITSCH M.(2); SKOWRONEK A.(3); LEE K.M.(1)
    (1) Altria Client Services, Richmond, VA, USA; (2) Philip Morris International, Neuchâtel, Switzerland; (3) Battelle, West Jefferson, OH, USA
    Cigarette smoking causes lung cancer, emphysema, and other serious diseases. While cessation remains the most effective approach to minimize smoking-related diseases, alternative nicotine delivery products that limit the generation of combustion...
  4. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 103

    Preclinical testing of flavors in e-vapor products - Part 1: Selection of representative flavor mixtures for toxicological evaluations using a structural grouping approach

    EHMAN K.D.(1); LANGSTON T.B.(1); KUMAR A.(1); LEE K.M.(1); SCIUSCIO D.(2); VANSCHEEUWIJCK P.(2); HOENG J.(2)
    (1) Altria Client Services, Richmond, VA, USA; (2) PMI R&D, Neuchâtel, Switzerland
    A variety of flavor ingredients are used in potentially reduced-risk tobacco or nicotine products, including e-vapor products. For this work, the ingredients were initially evaluated for quality and purity, which included assessment of food grade and...
  5. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 104

    Preclinical testing of flavors in e-vapor products - Part 2: Preparation and stability characterization of representative flavor mixtures

    SMITH C.R.(1); MILLER J.H. IV(1); SHAH N.(1); KUMAR A.(1); LEE K.M.(1); FRAUENDORFER F.(2); GUY P.(2); DIANA P.(2); GLABASNIA A.(2)
    (1) Altria Client Services, Richmond, VA, USA; (2) PMI R&D, Neuchâtel, Switzerland
    GLP guidelines require the characterization of test articles for preclinical biological studies to ensure the identity and composition are consistent from batch to batch and throughout the testing period. For e-vapor products, this would suggest that...
  7. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, AP 10

    Testing performance of tobacco varieties in water stress conditions

    CAMPANONI P.(1); LAPARRA H.(1); OZELLEY P.(1); DELLA CIANA P.(3); BISCARINI E.(3); MAURIZI L.(2); NARDONI N.(2); TRIPPELLA C.(2); GOEPFERT S.(1)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) Philip Morris Italia s.r.l., via Po 11-13-15, 00198, Roma, Italy; (3) L’Agricola s.r.l., Bastia Umbra, Perugia, Italy
    Increasing climate instability could lead to local agricultural constraints, presenting a risk for volumes and quality of tobacco supply. Selecting and breeding tobacco varieties for the ability to perform in unfavourable water conditions becomes a...
  8. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, AP 24

    Downregulation of a putative nitrate transporter gene substantially reduces the accumulation of TSNAs in air-cured tobaccos

    GOEPFERT S.(1); BOVET L.(1); LU J.(2); CAMPANONI P.(1); LEWIS R.S.(2); DEWEY R.E.(2)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) North Carolina State University, Department of Crop Science, Raleigh, NC, U.S.A.
    Air-cured Burley tobacco leaves typically exhibit high levels of nicotine-derived nitrosamine ketone (NNK) and N'-nitrosonornicotine (NNN). It has been previously demonstrated that leaf nitrate accumulation in air-cured tobaccos serves as the source...
  9. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, AP 49

    The influence of Nicotiana alata-derived introgression on plant malformations of tobacco breeding lines resistant to tomato spotted wilt virus

    KORBECKA-GLINKA G.(1); TROJAK-GOLUCH A.(1); DOROSZEWSKA T.(1); GOEPFERT S.(2)
    (1) Institute of Soil Science and Plant Cultivation - State Research Institute, Pulawy, Poland; (2) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    Tomato spotted wilt virus (TSWV) is one of the most destructive viruses for tobacco cultivation. Cultivar “Polalta” carries a resistance gene introgressed from a wild species, Nicotiana alata, but the use of this cultivar in breeding is hampered by...
  10. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 04

    Assessing the cytotoxicity of e-liquids without the use of the neutral red uptake assay

    McHUGH D.; CUDAZZO G.; VANSCHEEUWIJCK P.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    As part of the pre-clinical assessment performed for consumer products in the tobacco industry, an in vitro assessment of a tobacco product’s cytotoxicity was performed using the neutral red uptake (NRU) assay. Since 2004, the CORESTA In Vitro Task...