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1837 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, STPOST 13

    Application of rapid in vitro toxicological screening using ToxTracker to determine the effect of flavors in snus products.

    CARMINES E.(2); MISRA M.(2); OH S.(1); HENDRIK G.(3); COFFA B.G.(1,2); ALEKSA K.(1)
    (1) Labstat International, Kitchener, ON, Canada; (2) Chemular Inc., Hudson MI, U.S.A.; (3) Toxys Inc., CG Leiden, The Netherlands
    Snus is an oral tobacco derived nicotine product that is sold in flavored pre-packages. Snus is traditionally sold as tobacco flavored. The potential impact of flavors on toxicity is unknown. Regulatory assays such as Ames, neutral red uptake (NRU),...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, STPOST 14

    Comparison of urinary biomarkers of tobacco smoke exposure among different smokers

    GAO Yihan; LI Xiaonan; CUI Peicai; WANG Xuan; SHEN Yi
    Shanghai New Tobacco Product Research Institute, Pudong New Area, Shanghai, China
    Biomarkers of exposure (BoE) in human urine can reflect the smoke constituent exposure level and risk of smokers. To compare the changes in urinary metabolic markers of nicotine, tobacco specific nitrosamines (TSNAs), and other volatile organic...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, STPOST 15

    Effect of cigarette smoke on interfacial chemical properties of pulmonary surfactant

    LI Chao(1,2); ZHAO Qun(2); CHEN Longyu(2); FAN Duoqing(1); GUAN Ying(1); CHEN Fangrui(1); ZHU Zhouhai(1); WANG Lu(1); YANG Lei(1); PENG Qiyuan(1); MA Li(1); PAN Yi(2); LI Meng(1)
    (1) China Tobacco Yunnan Industrial Co., Ltd., Kunming, Yunnan, China; (2) Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan, China
    Cigarette smoke is the major source of indoor air pollution, and the lungs are the primary target organ affected by it. After entering the lungs, cigarette smoke first comes into contact with the pulmonary surfactant (PS) in the alveoli....
  4. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, STPOST 16

    Biomarkers assessment in healthy adult smokers who switched from conventional cigarettes to two types of non-combustible tobacco products: a randomized, controlled study

    YUKI D.*; GILES L.; HARBO S.; HEMSLEY A.
    JT International SA, Scientific & Regulatory Affairs, Geneva, Switzerland (* Now at Japan Tobacco Inc., Scientific & Regulatory Affairs, Tokyo, Japan)
    There has been a growing interest in the non-combustible tobacco products, including e-cigarettes and heated tobacco products. Reductions in biomarkers of exposure associated with selected harmful and potentially harmful constituents (HPHCs) have...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, STPOST 17

    Biomarkers assessment in healthy adult smokers who switched from conventional cigarettes to closed tank e-cigarette: a randomized, controlled study

    YUKI D.*; GILES L.; HARBO S.; HEMSLEY A.
    JT International SA, Scientific & Regulatory Affairs, Geneva, Switzerland (* Now at Japan Tobacco Inc., Scientific & Regulatory Affairs, Tokyo, Japan)
    There has been a growing interest on the non-combustible tobacco products, including e-cigarettes and heated tobacco products. Reductions in biomarkers of exposure associated with selected harmful and potentially harmful constituents (HPHCs) have...
  6. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, STPOST 18

    Comparison of biomarkers of exposure in users of various tobacco/nicotine products

    SCHERER M.; BURKHARDT T.; SCHERER G.; PLUYM N.
    ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany
    In the last two decades, various types of tobacco and nicotine products have been developed and marketed, which avoided combustion of tobacco and thus released much lower amounts of toxicants. These toxicants are almost exclusively combustion...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, STPOST 19

    Analysis of cannabidiol and its three major metabolites in human plasma by online extraction LC-MS/MS

    PLUYM N.; KANIS R.; RIEDEL K.; BURKHARDT T.; SCHERER G.; SCHERER M.
    ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany
    The main active ingredients of Cannabis sativa are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). CBD as the main non-psychoactive constituent has been marketed in a growing number of products for recreational use such as CBD oils and...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, STPOST 20

    White blood cell count is a biomarker of a potential harm in short-term smoking abstinence and product switching to electronic nicotine delivery systems

    MAKENA P.(1); CHEN P.(1); PRASAD G.L.(3); BAXTER S.A.(2)
    (1) RAI Services Company, Winston Salem, NC, U.S.A.; (2) BAT Investments Limited, R&D Centre, Southampton, U.K.; (3) Prasad Scientific Consulting LLC, Lewisville, NC, U.S.A.
    Smoking-related diseases develop over several decades of smoking and the adverse effects of smoking, such as chronic inflammation persist after cessation. Biomarkers of Potential Harm (BoPH) inform of interim biological responses to changes in...
  9. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, STPOST 21 (also presented at TSRC 2023)

    Aromatic amines in the mainstream smoke of commercial cigars

    JI Huihua(1); JIN Zhenyu(1); FENTON L.(1); SLONE S.(2)
    (1) Kentucky Tobacco Research and Development Center, University of Kentucky, Lexington, KY, U.S.A.; (2) Dr. Bing Zhang Department of Statistics, University of Kentucky, Lexington, KY, U.S.A.
    Aromatic amines are a class of carcinogenic compounds in tobacco smoke that are listed on the FDA list of harmful and potentially harmful constituents (HPHCs) in tobacco products and tobacco smoke. Six aromatic amines yields (1-aminonaphthalene...
  10. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, STPOST 22

    The effects of characterizing flavors on mainstream cigarette smoke chemistry and in vitro toxicity

    YOO Sohee; LEE Sanghoon; JANG Mi; YOO Jihye; JU Soyoung; CHOI Ikjang; MIN Hyejeong; PARK Chulhoon
    KT&G, R&D Headquarters, Daejeon, South Korea
    The employing of flavours in tobacco products has an extensive historical background, and recently, with the emergence of novel tobacco products, the importance of flavourings is growing steadily. Nonetheless, the flavours as the tobacco ingredient...