In most tobacco-growing areas of Greece, natural infestations of apterous aphids of the Myzus persicae / M. nicotianae complex group, colonizing on Samsoun Oriental tobacco, especially during the period from transplanting to the end of the growing period, tend to be very uneven in space and unpredictable in their time of onset or decline. These characteristics cause difficulties in applying the best program for aphid control in each area every year. For this purpose, many parameters should be studied for a long period, including the following:Aphid appearance, their biology, ecology and seasonal fluctuation; Neighbouring crops (e.g. peach orchards or several weeds) which may be used as primary hosts or reservoirs for aphids; Effect of predators and parasites; Chemicals used for aphid control and possible resistance. Furthermore, the combination of the above parameters with prevailing climatic conditions (temperature, relative humidity, winds) in the region during spring, and the recording of the alatae aphids-vectors of the non-persistent viruses (PVY, CMV, AMV), are also needed. Some solutions for a better aphid control in Katerini, one of the most important tobacco area in Greece, are expected to be found from this long research of the last decade. Here, the seasonal fluctuations in aphid infestation in the check (untreated) and in standard aphicide imidacloprid are presented, for comparison and application of a better one aphid control program in the area.