Since agrochemical residues are a topic of high concern for producers of plant products the presentation should provide an overview about the position of tobacco in context to other crops. Eurofins Dr. Specht Laboratorien as a highly specialized lab, only dedicated to analysis of agrochemicals is analyzing more than 70.000 plant origin samples per year. A brief introduction to major methodologies for the analytical determination of agrochemicals (with focus on the coverage of the CORESTA agrochemical guideline) will be given. Among tobacco material many fresh commodities (fruits and vegetables) as well as many tea samples are being analyzed in our lab. From that perspective a comparison of tobacco to other produces will be discussed in terms of different analytical behaviour, limit of quantification, degradation of agrochemicals, matrix effects and legislative regulations to be applied. Special attention will be drawn to regulatory affairs explaining the current EU pesticide MRL regulation vs. retailer specifications for fresh commodities vs. CORESTA GRL guidelines for tobacco. The residue situation of tobacco will be compared to other crops from the same country of origin in terms of qualitative and quantitative differences.