At the CORESTA Tobacco and Tobacco Products Analysis Sub-Group (TTPA) meeting held in September 2022, the Sub-Group initiated a collaborative study for the determination of nicotine impurities and degradants in nicotine pouch filler. The intent of this study was to propose a CORESTA Recommended Method (CRM) and to provide repeatability (r) and reproducibility (R) results and z-scores to support laboratory accreditation. Eight laboratories participated in the study.

The results of the study demonstrated that the proposed CRM was suitable for the analysis of nicotine impurities and degradants in nicotine pouch filler samples.  Following the TTPA Sub-Group's recommendation, the method was published as CRM 105 "Determination of Nicotine Impurities and Degradants in Nicotine Pouches by LC-MS/MS".