In May 2016, the U.S. Food and Drug Administration (FDA) published draft guidance entitled Premarket Tobacco Product Application for Electronic Nicotine Delivery Systems. In this document, FDA recommends reporting the quantities of designated Harmful and Potentially Harmful Constituents (HPHCs) in e-cigarettes and formulations (e-liquids). This work describes a sensitive and selective method for determining the five volatile organic compounds (VOCs) listed on the FDA Premarket Tobacco Product Application (PMTA) HPHC list in both formulations and aerosols. The VOCs include 1,3-butadiene, isoprene, acrylonitrile, benzene and toluene. Preparations of formulations require a simple dilution prior to analysis. Aerosol samples are collected using a Cambridge filter pad (using the puffing regimen of 55 cc puff, 5 second duration) followed by a single fritted impinger containing 20 mL of cryogenically cooled methanol. Samples are analyzed by GC-MS in selected ion monitoring mode (SIM). The method demonstrated acceptable linearity for all compounds over a concentration range of 0.05 to 20 µg/mL with coefficients of determination ≥ 0.995. The accuracy of the method was demonstrated through recovery studies of fortified formulations and aerosols resulting in recoveries between 80% and 120% for all analytes. The method limit of quantitation was determined to be 1.7-16.7 µg/g in formulation and 0.04-0.4 µg/puff in aerosol for the five VOCs.