Search Results

7 results

  1. CORESTA Meeting, Smoke Science/Product Technology, Jeju, 2007, SSPT 45

    Gene expression analysis of human lung cells treated with cigarette smoke

    ACHARD S.; VERRON T.; SEVESTRE O.; DUMERY B.
    Altadis - Imperial Tobacco Group, Research Center, Fleury les Aubrais, France
    Gene expression profiling is considered as a promising tool that may identify more sensitive, mechanism-based biomarkers. Such an experimental approach should provide a better understanding of the impact of chemical compounds on the intracellular...
  2. CORESTA Meeting, Smoke Science/Product Technology, Freiburg, 2003, ST 39

    Assessment of tar and nicotine yields obtained under natural conditions by smokers. Comparison of several groups of usual smokers

    MARCHAND V.; DELARUE B.; TESSIER C.; CHABRILLAT N.; FRETEY D.; CAHOURS X.; DUMÉRY B.
    Altadis - Imperial Tobacco Group, Research Center, Fleury les Aubrais, France
    We previously published results indicating that under natural conditions, smokers of superlight cigarettes produced on average less tar and nicotine than smokers of full flavour cigarettes, even if the ratio between the two groups was lower than...
  3. CORESTA Meeting, Smoke Science/Product Technology, Freiburg, 2003, ST 41

    Effects of middle-term switching from a full flavour to a light flavour brand on the smoking behaviour and on smoker's biomarkers of exposure

    DELARUE B.; TESSIER C.; CHABRILLAT N.; FRETEY D.; CAHOURS X.; DUMÉRY B.; MARCHAND V.
    Altadis - Imperial Tobacco Group, Research Center, Fleury les Aubrais, France
    Because the field of knowledge concerning the benefit for health to smoke lighter cigarettes is not very large, we wanted to look at the changes that may occur in the smoker behaviour after switching to lighter cigarettes, and to follow this...
  4. CORESTA Meeting, Smoke Science/Product Technology, Freiburg, 2003, ST 43

    Determining the nicotine and cotinine in saliva using automated column-switching high-performance liquid chromatography

    CAHOURS X.; CHABRILLAT N.; DUBOIS M.; DUMÉRY B.; MARCHAND V.
    Altadis - Imperial Tobacco Group, Research Center, Fleury les Aubrais, France
    The determination, of nicotine and its metabolite, cotinine, in saliva, is very often used to estimate active smoking behavior. However, the proposed methods are often expensive, time consuming and work intensive. Indeed, in the case of biofluids...
  5. CORESTA Congress, New Orleans, 2002, ST 16

    Cigarette smoke and nicotine protect dopaminergic neurons against the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Parkinsonian disease in mice

    MARCHAND V.; HAPDEY C.; PARAIN K.; ROUSSELET E.; DUMERY B.; HIRSCH E.
    Altadis - Imperial Tobacco Group, Research Center, Fleury les Aubrais, France
    Epidemiological studies have found a negative association between cigarette smoking and Parkinson's disease. In order to analyze the putative neuroprotective effect of cigarette smoke and nicotine, one of its major constituents, in parkinsonian...