1. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 54

    Indoor air chemistry (IAC): comparative study between conventional cigarette and heat-not-burn technology

    GOUJON C.; MAEDER S.
    Philip Morris International R&D, Neuchâtel, Switzerland
    Philip Morris International (PMI) is developing products with the potential to reduce the risk associated with smoking. The Electrically Heated Tobacco System (EHTS) operates by heating a tobacco stick with a holder at a controlled temperature. By heating ...
  2. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 78

    Predictability of in vitro toxicological assessments of cigarettes: analysis of seven years of regulatory submissions to Canadian authorities

    BELUSHKIN M.(1); PIADÉ J-J.(1); CHAPMAN S.(2); FAZEKAS G.(2)
    (1) Philip Morris International R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (2) Rothmans, Benson & Hedges Inc., Brampton, Ontario, Canada
    Canadian authorities have required the annual submission of a wealth of by-brand information about cigarettes – including analytical data for cut filler and mainstream smoke constituents, for more than a decade. In 2005, the reporting requirements were ...
  3. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, STPOST 21

    Evaluating the genotoxicity of tobacco smoke-derived aerosols using the flow cytometry-based in vitro micronucleus assay

    POULEAU B.; SMART D.J.; McHUGH D.
    Philip Morris International R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    The in vitro micronucleus (MN) assay is used to assess the genotoxic potential of a test substance by measuring the induction of micronuclei in cultured mammalian cells. The flow cytometry-based assay (in vitro MicroFlow ® kit, Litron Laboratories, USA) ...
  4. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, STPOST 23

    Quantitative evaluation of the mutagenicity induced by tobacco smoke-derived total particulate matter using the mouse lymphoma assay

    DEMOUTE A-L.; AL-JOBORI O.; POULEAU B.; SMART D.J.; McHUGH D.
    Philip Morris International R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    The mouse lymphoma assay (MLA) is a regulatory in vitro test deployed to evaluate the mutagenicity of a test substance via exposure of the thymidine kinase locus in L5178Y mouse lymphoma cells. As part of a proficiency study, we evaluated the mutagenicity ...
  5. Beitr. Tabakforsch. Int./Contrib. Tob. Research, 2002, 20-1, p. 15-22., ISSN.0173-783X.

    Bacillus thuringiensis (Bt) for the control of insect pests in stored tobacco: a review

    BLANC M.; KAELIN P.; GADANI F.
    Philip Morris Intl, R&D, c/o Philip Morris Products SA, Neuchâtel, Switzerland.
    Among the insect species causing infestations and serious damages to stored commodities, the cigarette beetle, Lasioderma serricorne (F.) and the tobacco moth, Ephestia elutella (Hübner) are the major pests of both raw and manufactured tobacco. Post ...
  6. CORESTA Congress, New Orleans, 2002, AP 33

    Quantitative determination of genetic modification markers in tobacco by high-throughput real time PCR

    ROSSI L.; PIJNENBURG H.; BINDLER G.; KOCHER S.; HÄRRI A.; GADANI F.; ZUBER J.
    Philip Morris Products SA, R&D, Neuchâtel, Switzerland.
    Analytical methods based on the polymerase chain reaction (PCR) are widely used to detect, identify and quantify genetically modified organisms (GMOs) in agricultural crops, food and feed. The determination of genetic identity facilitates the ...