Search Results

9 results

  1. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 022 (also presented at CORESTA SSPT2019)

    A seven-month systems toxicology inhalation study in C57BL/6 mice demonstrates reduced pulmonary inflammation and emphysema following smoking cessation or switching to e-vapor aerosol exposures

    KUMAR A.(1); KOGEL U.(2); TALIKKA M.(2); HOENG J.(2); PEITSCH M.(2); SKOWRONEK A.(3); LEE K.M.(1)
    (1) Altria Client Services, Richmond, VA, USA; (2) Philip Morris International, Neuchâtel, Switzerland; (3) Battelle, West Jefferson, OH, USA
    Cigarette smoking causes lung cancer, emphysema, and other serious diseases. While cessation remains the most effective approach to minimize smoking-related diseases, alternative nicotine delivery products that limit the generation of combustion by ...
  2. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 103

    Preclinical testing of flavors in e-vapor products - Part 1: Selection of representative flavor mixtures for toxicological evaluations using a structural grouping approach

    EHMAN K.D.(1); LANGSTON T.B.(1); KUMAR A.(1); LEE K.M.(1); SCIUSCIO D.(2); VANSCHEEUWIJCK P.(2); HOENG J.(2)
    (1) Altria Client Services, Richmond, VA, USA; (2) PMI R&D, Neuchâtel, Switzerland
    A variety of flavor ingredients are used in potentially reduced-risk tobacco or nicotine products, including e-vapor products. For this work, the ingredients were initially evaluated for quality and purity, which included assessment of food grade and GRAS ...
  3. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 104

    Preclinical testing of flavors in e-vapor products - Part 2: Preparation and stability characterization of representative flavor mixtures

    SMITH C.R.(1); MILLER J.H. IV(1); SHAH N.(1); KUMAR A.(1); LEE K.M.(1); FRAUENDORFER F.(2); GUY P.(2); DIANA P.(2); GLABASNIA A.(2)
    (1) Altria Client Services, Richmond, VA, USA; (2) PMI R&D, Neuchâtel, Switzerland
    GLP guidelines require the characterization of test articles for preclinical biological studies to ensure the identity and composition are consistent from batch to batch and throughout the testing period. For e-vapor products, this would suggest that the ...
  4. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 129 (also presented at CORESTA SSPT2017)

    A computational model to characterize the Vitrocell® cell exposure system for evaluation of aerosols

    CASTRO N.(1); ROSTAMI A.A.(1); OLDHAM M.J.(1); PITHAWALLA Y.B.(1); LUCCI F.(2); KUCZAJ A.(2)
    (1) Altria Client Services, Richmond, VA, USA; (2) Philip Morris International, Neuchâtel, Switzerland
    In vitro exposure systems can be used as tools for toxicological assessment of e-cigarette aerosols. The VITROCELL® exposure system is designed such that exposure of cell cultures to the aerosol occurs at the air/liquid interface, which is relevant to e ...
  5. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 20

    Evaluation of a biomarker of oxidative stress: the 8-iso prostaglandin F2α: prostaglandin F2α ratio in human plasma

    MILLER P.(1); NEWLAND K.(1); DZERK A.(1); FARMEN R.(1); TRAN C.T.(2); HAZIZA C.(2); PICAVET P.(2)
    (1) Celerion, Inc., Lincoln, NE, USA; (2) Philip Morris International, Neuchâtel, Switzerland
    F2-isoprostanes have been widely studied as biomarkers of oxidative stress for various indications, including smoking. Since both enzymatic biosynthesis and chemical lipid peroxidation can generate these biomarkers, there are various interpretations that ...
  6. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 62

    FTIR method for e-cigarette aerosol characterization

    RADTKE F.; SUSZ A.; MONNI R.; STOOP A.; VERBEECK J.; MAEDER S.
    Philip Morris International, Research & Development, Philip Morris Products S.A., Neuchâtel, Switzerland
    The global electronic cigarettes (e-cig) market and product variety is expected to continue growing over the next years. This growth is being accompanied with interest in methods to compare different products for many reasons, including potential future ...
  7. TSRC, Tob. Sci. Res. Conf., 2012, 66, abstr. 28

    CSEO – The cigarette smoke exposure ontology

    YOUNESI E.(1), COGGINS C.(2); ANSARI S.(3); HOENG J.(3); PEITSCH M.(3); HOFMANN-APITIUS M.(1)
    (1) Fraunhofer Institute for Algorithms and Scientific Computing SCAI, Sankt Augustin, Germany; (2) Carson Watts Consulting, King, NC, USA; (3) Philip Morris International R&D, Neuchâtel, Switzerland
    In the past years, significant progress has been made in the development and use of experimental settings for collection of massive and precise experimental data on tobacco exposure and the diseases induced by it. Despite the growing number of such data, ...
  8. TSRC, Tob. Sci. Res. Conf., 2010, 64, abstr. 37

    A review of the literature on the degree of "compensatory" smoking of low-delivery cigarettes

    COGGINS C.; DEMPSEY R.; ROEMER E.
    Carson Watts Consulting, King, NC, USA; Philip Morris International Management SA, Neuchâtel, Switzerland
    To review trends in measures of compensatory smoking behavior over time and by method of assessment.Introduction. An analysis of the papers published on "compensatory" smoking, observed when smokers switch to lower-yielding products from higher ...