Search Results

136 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 27

    Next generation product aerosol bubbled extracts show little to no effect in high content screening endpoints when compared to cigarette smoke bubbled extracts

    TRELLES STICKEN E.(1); WIECZOREK R.(1); BODE L.M.(1); SIMMS L.(2); STEVENSON M.(2)
    (1) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), BioToxLab, Hamburg, Germany; (2) Imperial Tobacco Limited, In vitro Research, Bristol, U.K.
    Tobacco-based and tobacco-free next generation products (NGPs) are understood to be a less harmful alternative to conventional combustible cigarettes. The objective of this study was to compare the in vitro biological response of cigarette smoke and a ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 34

    Next generation product aerosols induce lower biological activity than combusted cigarettes: a comparison of in vitro cell migration in the scratch wound assay

    RUDD K.(1); BUDDE J.(2); TRELLES STICKEN E.(2); WIECZOREK R.(2); SIMMS L.(1); STEVENSON M.(1)
    (1) Imperial Brands PLC, Bristol, U.K.; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany
    Smoking combustible cigarettes is a cause of serious diseases in smokers, including heart disease. There are many commercially available next generation products (NGPs), such as tobacco-free e-vapour products, aiming to provide an alternative to smoking ...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 37

    Use of cell media nicotine concentration as a marker to predict cells surface deposited nicotine in transwells after fresh smoke/aerosol exposure

    WIECZOREK R.(1); TRELLES STICKEN E.(1); BODE L.M.(1); SIMMS l.(2)
    (1) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany; (2) Imperial Tobacco Limited, Bristol, U.K.
    Exposure of organotypic 3D lung models at the air liquid interface (ALI) to fresh whole smoke/aerosol provides a more human relevant exposure assessment of combustible cigarettes and e-vapour products. The aim of this study is to present a method for ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STW 01

    The application of in vitro Toxicity Testing in 21 Century (TT21C) for next generation products

    SIMMS L.(1); TRELLES STICKEN E.(2)
    (1) Imperial Brands PLC, Bristol, U.K.; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany
    The aim is to demonstrate the feasibility of TT21C in vitro methods as part of an overall assessment framework for next generation products (NGP). TT21C methodologies can be used to assess harm reduction potential of NGPs using human-derived cellular ...
  5. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 057

    CTP submissions – tips and insight for preparing an electronic submission

    SMITH J.K.(1); SHOLTES D.(1); GLATSTEIN S.(1); ANGERMEIER G.(2)
    (1) US Food and Drug Administration (FDA), Silver Spring, MD, USA; (2) WiseDesign, McLean, VA, USA
    Currently, tobacco product submissions are organized differently across application types and often, across applicants, and are received in a format that is not amenable for reviewers to organize and easily find what they need. This “unstructured” format ...
  6. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 079

    Comparison of the acetaldehyde, formaldehyde, and acrolein yields in cigars under different smoking regimens using a linear cigarette smoking machine

    YOUNG M.; CECIL T.L.; JOHNSON T.; FENG S.
    US Food and Drug Administration (FDA), Calverton, MD, USA
    Currently, there is very little information on the mainstream smoke yields of carbonyl compounds (e.g., formaldehyde, acetaldehyde, and acrolein) in cigar tobacco products. This study used a standard linear smoking machine and puffing protocols to provide ...
  7. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 091

    Tobacco-specific nitrosamines in the mainstream smoke of commercial little cigars

    EDWARDS S.H.(1); HASSINK M.(1); TAYLOR K.M.(1); WATSON C.(2); KUKLENYIK P.(2); WANG R.(2); CHEN P.(2); VALENTIN-BLASINI L.(2); KIMBRELL B.(2)
    (1) US Food and Drug Administration (FDA), Silver Spring, MD, USA; (2) Centers for Disease Control and Prevention, Atlanta, GA, USA
    Cigars are among the broad variety of deemed tobacco products that have been less extensively studied and characterized than cigarettes. Small sheet-wrapped cigars, often called little cigars, are a subcategory of cigars that are similar to conventional ...
  8. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 048

    Survey of nicotine, NNK, NNN, pH and physical properties of little cigars in the US market place

    LIU Youbang(1); HASSINK M.D.(1); TAYLOR K.M.(1); WATSON C.(2); CHAFIN D.(2); LAWLER T.(2); VALENTIN-BLASINI L.(2); KIMBRALL B.(2)
    (1) U.S. Food and Drug Administration, Silver Spring, MD, USA; (2) Centers for Disease Control and Prevention, Atlanta, GA, USA
    In May 2016, the jurisdiction of the Federal Food Drug and Cosmetic Act was extended to include all tobacco products, including cigars. Because limited information exists on the chemistry of cigar filler and smoke, 60 brands of popular little cigars sold ...