1. CORESTA Congress, Berlin, 2016, Agronomy/Phytopathology Groups, AP 51

    Potato virus Y (PVY) resistance in tobacco: identification of an alternative source of resistance against PVY resistant breaking variant

    JULIO E.(1); COTUCHEAU J.(1); DECORPS C.(1); VOLPATTI R.(1); MICHEL V.(2); GERMAN RETANA S.(2); DECROCQ V.(2); CANDRESSE T.(2); DORLHAC DE BORNE F.(1)
    (1) Imperial Tobacco, Bergerac, France; (2) UMR 1332 BFP, INRA, Univ Bordeaux, Villenave d'Ornon, France
    Potato virus Y (PVY) is one of the most damaging viruses on tobacco worldwide. This virus is responsible for mosaic or necrotic symptoms depending on the PVY strain. Aggressive PVY necrotic strains can lead to considerable yield losses. A large...
  2. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 04

    Reduction of harmful or potentially harmful constituents (HPHCs) following partial or complete substitution of cigarettes with electronic cigarettes in adult smokers

    D’RUIZ C.D.(1); O’CONNELL G.(2); GRAFF D.W.(3)
    (1) Scientific Affairs Consultant, Fontem Ventures, B.V., Greensboro, NC, U.S.A.; (2) Fontem Ventures, B.V., Scientific and Regulatory Affairs, Amsterdam, The Netherlands; (3) Celerion, Lincoln, NE, U.S.A.
    Changes in fifteen urine, blood, and exhaled breath biomarkers of exposure (BoE) to harmful and potentially harmful constituents (HPHCs), representing major classes of compounds reported by the FDA to be significant contributors to smoking-associated...
  3. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 06

    Evaluation of a biomarker of oxidative stress: 8-iso-prostaglandin F2α / prostaglandin F2α ratio

    NEWLAND K.(1); MILLER P.(1); FARMEN R.(1); TRAN C.T.(2); HAZIZA C.(2); PICAVET P.(2)
    (1) Celerion, Inc., Lincoln, NE, U.S.A.; (2) Philip Morris Products S.A. (part of Philip Morris International group of companies), Neuchâtel, Switzerland
    It is understood that exposure to free radicals related to tobacco use negatively impacts smoker health. Studies have been performed measuring fatty acid oxidation products (F2-Isoprostanes) in human urine as biomarkers of harm from free radical...
  4. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 23

    Pharmacokinetics of nicotine following single controlled use of a new type of tobacco: heated tobacco product

    GILES L.(1); YUKI D.(2); SHERWOOD N.(3); GRAFF D.W.(4); NEWLAND K.(4)
    (1) JT International SA, Ballymena, Co. Antrim, U.K.; (2) Japan Tobacco Inc., Yokohama, Kanagawa, Japan; (3) Neil Sherwood Consulting, Commugny, Switzerland; (4) Celerion, Lincoln, NE, U.S.A.
    Nicotine is one of the most characteristic compounds contained in any type of tobacco product including cigarettes. Previous studies have reported that different types of tobacco products display differences in nicotine pharmacokinetics. NHTP is a...
  5. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 48

    The proposed use of human cells to cover the ‘R’ end point for EUTPD2 data requirements from a 21st century toxicology perspective

    SIMMS L.(1); PALMER J.(2)
    (1) Imperial Tobacco Limited, Bristol, U.K.; (2) Stemina, Madison, WI, U.S.A.
    In 2007 the National Academies of Sciences released “Toxicity Testing in the 21st Century: A Vision and a Strategy”, a new toxicological paradigm, moving away from the idea of high dose animal tests as the ‘gold standard’ and focusing on the use of...
  6. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 18

    Assessment of the so-called “gateway effect” based on electronic vapour product classifications

    VERRON T.(1); CAHOURS X.(1); CERSON L.(2); COLARD S.(1); O’CONNELL G.(3)
    (1) SEITA-Imperial Tobacco, Fleury-les-Aubrais, France; (2) Imperial Tobacco Limited, Bristol, U.K.; (3) Fontem Ventures B.V., Amsterdam, Netherlands
    Since electronic cigarettes (e-cigs) became popular as alternatives to conventional cigarettes, with subsequent market growth amongst smokers, there is currently a debate as to whether e-cigs may be a "gateway" to conventional cigarette smoking or...
  7. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 32

    Cellular transformation activity of different tobacco condensates in the Bhas 42 cell assay

    STEVENSON M.(1); WIECZOREK R.(2); SIMMS L.(1); PANT K.(3)
    (1) Imperial Tobacco Limited, Bristol, U.K.; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany; (3) BioReliance, Sigma-Aldrich Corp., Rockville, MD, U.S.A.
    Carcinogenesis has been described as a multi-stage process comprising of initiation, promotion and progression. Smoking is a cause of serious disease in smokers, including lung cancer. Determining the carcinogenic potential of a tobacco product...
  8. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 20

    Evaluation of a biomarker of oxidative stress: the 8-iso prostaglandin F2α: prostaglandin F2α ratio in human plasma

    MILLER P.(1); NEWLAND K.(1); DZERK A.(1); FARMEN R.(1); TRAN C.T.(2); HAZIZA C.(2); PICAVET P.(2)
    (1) Celerion, Inc., Lincoln, NE, USA; (2) Philip Morris International, Neuchâtel, Switzerland
    F2-isoprostanes have been widely studied as biomarkers of oxidative stress for various indications, including smoking. Since both enzymatic biosynthesis and chemical lipid peroxidation can generate these biomarkers, there are various interpretations...
  9. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 23

    Reductions in biomarkers of exposure (BoE) to harmful or potentially harmful constituents (HPHCs) following partial or complete substitution of cigarettes with electronic cigarettes in adult smokers

    O’CONNELL G.(1); GRAFF D.W.(2); D’RUIZ C.(3)
    (1) Fontem Ventures B.V, Amsterdam, The Netherlands; (2) Celerion Inc, Lincoln, NE, USA; (3) Fontem Ventures B.V Greensboro, NC, USA
    Changes in fifteen urine, blood and exhaled breath BoEs of HPHCs representing classes of compounds reported by FDA to be significant contributors to smoking-associated disease risks were measured in 105 clinical-confined subjects following...