Search Results

116 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 53

    NNN – a suitable biomarker of exposure from smoke and new nicotine delivery products?

    PLUYM N.; TAUCHER J.; SCHERER G.; SCHERER M.
    ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany
    N-Nitrosonornicotine (NNN) is believed to play a critical role in the development of cancer in tobacco users and was therefore classified by the International Agency for Research on Cancer (IARC) as a Group 1 carcinogen. Hence, urinary NNN is commonly ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 54

    Clinical biomarkers of compliance for use in potentially reduced-risk product switching studies

    McEWAN M.(1); GALE N.(1); HARDIE G.(1); SCHERER M.(2); PLUYM N.(2); EBAJEMITO J.K.(1); CAMACHO O.M.(1); GRIFFITHS A.(1); PROCTOR C.J.(1)
    (1) British American Tobacco (Investments) Limited, Research and Development, Southampton, U.K.; (2) ABF GmbH, Planegg, Germany
    Preclinical assessments and clinical studies have shown significant reductions in toxicants in tobacco heating product (THP) aerosols compared to smoke from conventional cigarettes. Further studies to assess if these toxicant reductions translate to ...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 13

    Analysis of propylene oxide and glycidol in tobacco smoke and e-cigarette vapour

    LANDMESSER A.; SCHERER G.; PLUYM N.; SCHERER M.
    ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany
    We recently performed a clinical study with e-cigarette users (vapers) and smokers. The stable-isotope labeled e-cigarette constituents propylene glycol, glycerol, and nicotine in the test e-cigarette were used in order to investigate the e-cigarette ...
  4. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups (Workshop), STW 07

    Identifying suitable biomarkers of biological effects (BOBEs) for evaluating reduced risk products

    SCHERER G.; PLUYM N.; SCHERER M.
    ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany
    Switching from conventional cigarettes (CCs) to reduced risk products (RRPs), such as e cigarettes, heat-not-burn and oral tobacco products, could be an effective approach for tobacco harm reduction (THR), provided that the use of RRPs effectively entails ...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 59

    An inter-laboratory comparison study focused on the determination of total NNAL in human urine

    NEWLAND K.(1); SCHERER M.(2); HECHT S.S.(3); TROUDE V.(4); PRASAD G.L.(5)
    (1) Celerion Inc., Lincoln, NE, U.S.A.; (2) ABF GmbH, Planegg, Germany; (3) University of Minnesota Cancer Center, Minneapolis, MN, U.S.A.; (4) Reemtsma Cigarettenfabriken GmbH, Imperial Brands plc, Hamburg, Germany; (5) RAI Services Company, Winston-Salem, NC, U.S.A.
    In an ongoing effort to fulfil the second objective of the CORESTA Biomarker Sub-Group, periodic inter-laboratory comparison studies have been performed to evaluate the consistency of the quantitation for various harmful or potentially harmful exposure ...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 61

    Novel biomarkers to characterize exposure to aldehydes from e-vapor products based on stable-isotope constituents

    LANDMESSER A.(1); SCHERER M.(1); SCHERER G.(1); SARKAR M.(2); EDMISTON J.S.(2); PLUYM N.(1)
    (1) ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany; (2) Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    E vapor products (EVP) are an emerging category of non-combustible tobacco products that hold the promise of harm reduction for users of combustible products. Degradation products such as aldehydes have received much attention lately, however human ...
  7. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 40

    Analytical methods for the determination of aldehydes in e-vapor aerosol and cigarette smoke and their urinary biomarkers of exposure

    LANDMESSER A.(1); SCHERER M.(1); SCHERER G.(1); SARKAR M.(2); EDMISTON J.S.(2); PLUYM N.(1)
    (1) ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany; (2) Altria Client Services, Center for Research and Technology, Richmond, VA, U.S.A.
    Potential exposure to aldehydes, such as acrolein, formaldehyde or acetaldehyde, formed due to thermal degradation of the e-liquid constituents propylene glycol (PG) and glycerol (G) during the consumption of e-vapor products (EVPs), have received much ...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 23

    Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – clinical study design

    SCHERER M.(1); LANDMESSER A.(1); PLUYM N.(1); SCHERER G.(1); SARKAR M.(2); EDMISTON J.(2)
    (1) ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany; (2) Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    E-vapor products (EVPs) are becoming an accepted alternative to conventional cigarettes among smokers. Despite the increasing popularity of EVPs, little information exists on the fate of the main ingredients glycerol (G), propylene glycol (PG) and ...
  9. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 24

    Biomarkers of exposure specific to e-vapour products based on stable-isotope labelled ingredients – results

    PLUYM N.(1); LANDMESSER A.(1); SCHERER M.(1); SCHERER G.(1); SARKAR M.(2); EDMISTON J.(2)
    (1) ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany; (2) Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    E-vapor products (EVPs) consumption has steadily increased worldwide over the past decade. Ever since their introduction, there have been discussions about the potential health risks of EVPs in the scientific and public health community. These discussions ...
  10. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 43

    Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – methods

    SCHERER M.(1); LANDMESSER A.(1); PLUYM N.(1); SCHERER G.(1); SARKAR M.(2); EDMISTON J.(2)
    (1) ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany; (2) Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    E-vapor products (EVPs) are becoming an accepted alternative for nicotine delivery amongst smokers. The popularity of EVPs has been increasing and more systematic research is required in order to assess the impact of e-cigarette use-related exposure to ...