TSRC, Tob. Sci. Res. Conf., 2012, 66, abstr. 07
Complete artificial saliva alters expression of proinflamma-tory cytokines in human dermal fibroblasts
(1) Wake Forest University Health Sciences, Winston-Salem, NC, USA; (2) R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA
Complete artificial saliva (CAS) is a saliva substitute often used as a vehicle for test articles, including, smokeless tobacco. We discovered, using polymerase chain reaction gene expression array analyses, that CAS increased gene expression for certain ...