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151 results

  1. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, AP 11

    Breeding of an extremely low nicotine Burley tobacco line and its characteristics

    NA Woong-Hyun; KIM Kwang-Chul; OH Kyung-Hwan; JEON Eun-Young; LEE Jeong-Heon
    KT&G R&D Headquarters, Daejeon, South Korea
    Worldwide, regulation on tobacco and cigarettes is increasing more and more. In addition, the U.S. Food and Drug Administration (FDA) has recently announced a plan for regulation of nicotine content in tobacco. In this situation, not only flue-cured ...
  2. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 02

    Effect of heating temperature on chemical characterisation and biological activity of tobacco smoke emission

    SHIN Han-Jae; GWAK Hyo-Min; LEE Moon-Yong
    KT&G Research Institute, Daejeon, South Korea
    Cigarette smoke is mainly produced by distillation, pyrolysis and combustion reactions when the tobacco is burnt. Heating type cigarettes have been reported to have the potential to reduce or eliminate some toxicants found in cigarette smoke because ...
  3. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 11

    Determination of the transfer of nicotine and selected ingredients into heat-not-burn tobacco product mainstream aerosol by using gas chromatography

    YUN J.H.; JIN S.J.; LIM G.H.; LEE J.M.
    KT&G Research Institute, Daejeon, South Korea
    Recently, tobacco manufacturing companies launched heat-not-burn tobacco products (HNBs) such as iQOS, Glo and lil. The aerosol of HNBs is generated by the heating of a tobacco type material below 350 °C. In conventional cigarettes the aerosol is formed ...
  4. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 62

    Immune functions are perturbed to a greater extent with smoking rather than moist snuff use

    TRAN Q.T.(1); ARIMILLI S.(2); JOHNSON E.(3); LIU Gang(1); PRASAD G.L.(1)
    (1) RAI Services Company, Winston-Salem, NC, U.S.A.; (2) Wake Forest University, School of Medicine, Department of Microbiology and Immunology, Winston-Salem, NC, U.S.A.; (3) University of North Carolina, Department of Mathematics and Statistics, Greensboro, NC, U.S.A.
    Cigarette smoking is a major risk factor for lung cancer, chronic obstructive pulmonary disease, and cardiovascular disease (CVD). Existing epidemiological data suggest moist snuff consumption is generally associated with reduced health risks relative to ...
  5. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 066

    Distinct gene expression changes in peripheral blood mononuclear cells exposed to combustible versus non-combustible tobacco product preparations

    TRAN N.Q.(1); ARIMILLI S.(2); MADAHIAN B.(3); HOMAYOUNI R.(3); PRASAD G.L.(1)
    (1) RAI Services, Winston-Salem, NC, USA; (2) Wake Forest University, Winston-Salem, NC, USA; (3) Quire Inc., Memphis, TN, USA
    Cigarette smoking exerts diverse physiological effects including immune suppression. Existing epidemiological data show that consumption of smokeless tobacco products, such as moist snuff, is less harmful relative to smoking. We previously demonstrated ...
  6. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 080

    Differential gene expression and functional responses in peripheral blood mononuclear cells pretreated with combustible and non-combustible tobacco products

    TRAN Q.T.(1); ARIMILLI S.(2); LIU Gang(1); MAKENA P.(1); PRASAD G.L.(1)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Wake Forest School of Medicine, Winston-Salem, NC, USA
    Chronic smoking is known to alter immune responses, which compromises tumor surveillance and host defense against microbial infections. We previously showed that smokers (SMK) exhibit distinct peripheral blood mononuclear cell (PBMC) gene expression ...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 49

    Mouth level exposure estimation of nicotine and NFDPM by applying part-filter analysis from smokers of super-slim and regular size cigarettes

    HAN Eun-Jung; LEE Jeong-Min; LEE Hye-Jung; KIM Ji-Hye; HYUN Hak-Chul; JANG Gi-Chul
    KT&G Research Institute, Daejeon, South Korea
    In recent years the super-slim cigarette market of low and medium tar products steadily increased in East Asian countries. According to statistical data in Korea, the market share of super-slim products in Korea steadily increased from 20 % in 2012, up to ...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 19

    Combustible and smokeless tobacco product preparations differentially regulate calcium mobilization in the human leukemic HL60 cell line

    MAKENA P.(2); ARIMILLI S.(1); DAMRATOSKI B.E.(1); PRASAD G.L.(2)
    (1) Wake Forest University School of Medicine, Department of Microbiology & Immunology, Winston-Salem, NC, U.S.A.; (2) RAI Services Co., Winston-Salem, NC 27102, U.S.A.
    Increased calcium (Ca 2+) mobilization is central to leukocyte signaling and for regulation of immune responses. Although evidence suggests that cigarette smoking affects several biological functions including inflammatory responses, how the use of ...
  9. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 26

    A review of aerosol exposure systems relative to the analysis of cytotoxicity: a CORESTA In vitro Toxicity Testing Sub-Group perspective

    THORNE D.(1); WIECZOREK R.(2); FUKUSHIMA T.(3); SHIN H.J.(4); LEVERETTE R.(5); BALLANTYNE M.(6); LI X.(7); BOMBICK B.(5)
    (1) British American Tobacco, R&D Centre, Southampton, U.K.; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany; (3) Japan Tobacco Inc., Scientific Product Assessment Centre, Yokohama, Kanagawa, Japan; (4) KT&G Corporation, Daejeon, South Korea; (5) RAI Services Company, Winston-Salem, NC, U.S.A.; (6) Covance Laboratories Ltd, Harrogate, U.K.; (7) Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, P.R. China
    Aerosol exposure systems offer researchers a variety of ways to customise the exposure set-up, modify experimental parameters and provide a novel and versatile platform for in vitro aerosol research. These systems produce an aerosol that more closely ...
  10. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 40

    Role of oxidative stress in the suppression of immune responses in peripheral blood mononuclear cells exposed to combustible tobacco product preparations

    PRASAD G.L.(1); ARIMILLI S.(2); DAMRATOSKI B.E.(2)
    (1) Scientific & Regulatory Affairs, RAI Services Company, Winston-Salem, U.S.A.; (2) Department of Microbiology & Immunology, Wake Forest University Health Sciences, U.S.A.
    Cigarette smoking is a major risk factor for several human diseases. Chronic inflammation, resulting from increased oxidative stress, has been suggested as a mechanism that contributes to the increased susceptibility of smokers to cancer and microbial ...