Search Results

23 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 53

    NNN – a suitable biomarker of exposure from smoke and new nicotine delivery products?

    PLUYM N.; TAUCHER J.; SCHERER G.; SCHERER M.
    ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany
    N-Nitrosonornicotine (NNN) is believed to play a critical role in the development of cancer in tobacco users and was therefore classified by the International Agency for Research on Cancer (IARC) as a Group 1 carcinogen. Hence, urinary NNN is commonly ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 54

    Clinical biomarkers of compliance for use in potentially reduced-risk product switching studies

    McEWAN M.(1); GALE N.(1); HARDIE G.(1); SCHERER M.(2); PLUYM N.(2); EBAJEMITO J.K.(1); CAMACHO O.M.(1); GRIFFITHS A.(1); PROCTOR C.J.(1)
    (1) British American Tobacco (Investments) Limited, Research and Development, Southampton, U.K.; (2) ABF GmbH, Planegg, Germany
    Preclinical assessments and clinical studies have shown significant reductions in toxicants in tobacco heating product (THP) aerosols compared to smoke from conventional cigarettes. Further studies to assess if these toxicant reductions translate to ...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 13

    Analysis of propylene oxide and glycidol in tobacco smoke and e-cigarette vapour

    LANDMESSER A.; SCHERER G.; PLUYM N.; SCHERER M.
    ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany
    We recently performed a clinical study with e-cigarette users (vapers) and smokers. The stable-isotope labeled e-cigarette constituents propylene glycol, glycerol, and nicotine in the test e-cigarette were used in order to investigate the e-cigarette ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 23

    Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – clinical study design

    SCHERER M.(1); LANDMESSER A.(1); PLUYM N.(1); SCHERER G.(1); SARKAR M.(2); EDMISTON J.(2)
    (1) ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany; (2) Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    E-vapor products (EVPs) are becoming an accepted alternative to conventional cigarettes among smokers. Despite the increasing popularity of EVPs, little information exists on the fate of the main ingredients glycerol (G), propylene glycol (PG) and ...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 24

    Biomarkers of exposure specific to e-vapour products based on stable-isotope labelled ingredients – results

    PLUYM N.(1); LANDMESSER A.(1); SCHERER M.(1); SCHERER G.(1); SARKAR M.(2); EDMISTON J.(2)
    (1) ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany; (2) Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    E-vapor products (EVPs) consumption has steadily increased worldwide over the past decade. Ever since their introduction, there have been discussions about the potential health risks of EVPs in the scientific and public health community. These discussions ...
  6. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 19

    Combustible and smokeless tobacco product preparations differentially regulate calcium mobilization in the human leukemic HL60 cell line

    MAKENA P.(2); ARIMILLI S.(1); DAMRATOSKI B.E.(1); PRASAD G.L.(2)
    (1) Wake Forest University School of Medicine, Department of Microbiology & Immunology, Winston-Salem, NC, U.S.A.; (2) RAI Services Co., Winston-Salem, NC 27102, U.S.A.
    Increased calcium (Ca 2+) mobilization is central to leukocyte signaling and for regulation of immune responses. Although evidence suggests that cigarette smoking affects several biological functions including inflammatory responses, how the use of ...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 43

    Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – methods

    SCHERER M.(1); LANDMESSER A.(1); PLUYM N.(1); SCHERER G.(1); SARKAR M.(2); EDMISTON J.(2)
    (1) ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany; (2) Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    E-vapor products (EVPs) are becoming an accepted alternative for nicotine delivery amongst smokers. The popularity of EVPs has been increasing and more systematic research is required in order to assess the impact of e-cigarette use-related exposure to ...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2015, Jeju, ST 13

    Impact of smoking cessation on the metabolomic profile of former smokers

    GÖTTEL M.; MÜLLER D.; PLUYM N.; SCHERER G.; SCHERER M.
    ABF Analytisch-Biologisches Forschungslabor GmbH, Munich, Germany
    Smoking is known to cause several diseases. However, the underlying pathophysiological mechanisms are still not completely understood. In order to prevent these diseases it is of paramount importance to identify biomarkers helping to decipher the root ...
  9. CORESTA Meeting, Smoke Science/Product Technology, 2015, Jeju, STPOST 12

    Determination of flavours and their metabolites in e-liquids and biological fluids – identification of biomarkers of exposure to prominent e-cigarette flavours

    RIEDEL K.; PLUYM N.; SCHERER G.; SCHERER M.
    ABF Analytisch-Biologisches Forschungslabor GmbH, Munich, Germany
    E-cigarette use, also referred to as vaping, is increasing worldwide as these products are becoming a preferred alternative for conventional cigarettes among smokers. Almost all e-cigarette liquids (e-liquids) contain flavour chemicals. Although the ...
  10. CORESTA Meeting, Smoke Science/Product Technology, 2015, Jeju, STPOST 22

    A novel method for the determination of propylene glycol and glycerine from various biological matrices – suitable biomarkers for e-cigarette consumption

    HAGEDORN H.W.; PLUYM N.; SCHERER G.; SCHERER M.
    ABF Analytisch-Biologisches Forschungslabor GmbH, Munich, Germany
    Despite the popularity e-cigarettes have gained worldwide, very little rigorous research has been performed in terms of product control and the effects of these devices on human health. The systematic and objective assessment of the actual dose by ...