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63 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 12

    Determination of nicotine in gas vapour phase in phosphate buffered saline by UHPLC-MS/MS

    HOLLINGS M.(1); THOMPSON N.(2); LARNER J.(1); CLEMENTS J.(1)
    (1) Covance Laboratories Ltd, Harrogate, North Yorkshire, U.K.; (2) Broughton Nicotine Services, Earby, Lancashire, U.K.
    A liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method was developed to quantify nicotine in gas vapour phase (GVP) collected in calcium and magnesium free phosphate buffered saline (CMF-PBS). In this method the aerosol was trapped in ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 42

    Characterization of whole mainstream smoke/aerosol delivery within the Vitrocell® Ames 48 high throughput exposure module using different tobacco product types

    LEVERETTE R.(1); KEYSER B.(1); SEYMOUR A.(2); HOLLINGS M.(2)
    (1) RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.; (2) Covance Laboratories Ltd, Otley Road, Harrogate, North Yorkshire, U.K.
    The preferred means of assessing combustible or other aerosol-generating tobacco products in vitro is by direct exposure of cell cultures to freshly generated whole mainstream smoke/aerosols. This approach eliminates the fractionation of smoke/aerosols ...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 43

    Dosimetric analysis of aerosol generated by a Vitrocell® VC10® Smoking Robot – investigations on dose dependency and consistency of application

    SEYMOUR A.; HOLLINGS M.; LARNER J.; CLEMENTS J.
    Covance Laboratories Ltd, Harrogate, North Yorkshire, U.K.
    Quartz Crystal Microbalances were used to assess the suitability of the Vitrocell ® VC10 ® exposure system. The main objective of the study was to deliver smoke aerosol in a consistent and dose dependent manner across a range of module formats. Dose ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 49

    The CORESTA in vitro test battery for combustible tobacco products: update from the 2004 Rationale and Strategy Report

    LEE K.M.(1); JORDAN K.G.(2); WIECZOREK R.(3); MOENNIKES O.(4); CLEMENTS J.(5); CROOKS I.(6); HASHIZUME T.(7); MILLER J.(8); WEBER E.(9); YOSHINO K.(7)
    (1) Altria Client Services, Richmond, VA, U.S.A.; (2) RAI Services Company, Winston-Salem, NC, U.S.A.; (3) Imperial Brands, Reemtsma Cigarettenfabriken GmbH, Hamburg, Germany; (4) PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (5) Covance Laboratories Ltd, Harrogate, U.K.; (6) British American Tobacco (Investments) Ltd, R&D, Southampton, U.K.; (7) Japan Tobacco Inc., Yokohama, Kanagawa, Japan; (8) JT International SA, Geneva, Switzerland; (9) Ökolab, Vienna, Austria
    In 2004, the CORESTA In Vitro Toxicity Task Force issued a rationale and strategy report, commonly known as “the CORESTA in vitro test battery guideline”. The goals of this guideline were to: 1) develop the rationale and strategy for conducting in vitro ...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 58

    A consortium approach for consumer-reported outcome measures to assess tobacco- and nicotine-containing products

    ACQUADRO C.(1) on behalf of the CORESTA CROM Task Force: AYALA-FIERRO F.(2); BLACK R.(3); CAHOURS X.(4); CHREA C.(5); CURTIN G.(6); GILES L.(7); McCAFFREY S.(3); PARK C.H.(8); PRASAD K.(9); SHERWOOD N.(10); SHIFFMAN S.(11); SMITH J.(6); SPIES E.(5)
    (1) Mapi Research Trust, Lyon, France; (2) ITG Brands, Greensboro, NC, U.S.A.; (3) Altria Client Services, Richmond, VA, U.S.A.; (4) SEITA - Imperial Brands, Paris, France; (5) Philip Morris Products S.A., Neûchatel, Switzerland; (6) RAIS, Winston-Salem, NC, U.S.A.; (7) JT Int'l SA, Genève, Switzerland; (8) KT&G Research Institute, Daejeon, Republic of Korea; (9) British American Tobacco, Southampton, U.K.; (10) Neil Sherwood Consulting, Commugny, Switzerland; (11) Pinney Associates, Pittsburgh, PA, U.S.A.
    In the tobacco space, consumer-reported outcome measures (CROM) are essential for understanding motivations, subjective effects, and behavior. Such measures have become particularly important with the advent of candidate modified risk tobacco products ...
  6. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 049

    High throughput air liquid interface exposure modules: characterization of smoke/aerosol dosimetry and in vitro mutagenicity and cytotoxicity of two tobacco product types

    LEVERETTE R.(1); KEYSER B.(1); HOLLINGS M.(2); SEYMOUR A.(2)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Covance Laboratories, North Yorkshire, UK
    The utilization of whole smoke/aerosol exposure systems provides a means to conduct in vitro assessments of freshly generated whole smoke/aerosol from combustible cigarettes and tobacco heating products (THPs), as well as electronic nicotine delivery ...
  7. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 52 (also presented at TSRC 2018)also presented at TSRC 2018)

    Consumers’ perceptions of disease-specific modified-risk claims are best evaluated in a disease-specific manner

    SHIFFMAN S.(1); CURTIN G.(2)
    (1) Pinney Associates, Pittsburgh, PA, U.S.A.; (2) RAI Services Company, Winston-Salem, NC, U.S.A.
    Manufacturers seeking to make claims about modified-risk tobacco products (MRTPs) must assess consumers' perceptions of risk reduction for these products. Claims made for the MRTP and assessment of perceived risk reduction can be global (e.g. &quot ...
  8. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 53 (also presented at TSRC 2018)

    Comparing direct and indirect assessments of perceptions of reduced risk for a modified-risk tobacco product

    SHIFFMAN S.(1); CURTIN G.(2)
    (1) Pinney Associates, Pittsburgh, PA, U.S.A.; (2) RAI Services Company, Winston-Salem, NC, U.S.A.
    Manufacturers seeking to make claims about modified-risk tobacco products (MRTPs) must assess consumers' perceptions of absolute and relative risks for these products. We cross-validate data from two methods: (a) indirect assessments based on the ...
  9. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 12 (also presented at TSRC 2018)

    Characterization of the Vitrocell® high throughput exposure modules using different tobacco product types

    LEVERETTE R.(1); KEYSER B.(2); SEYMOUR A.(2); HOLLINGS M.(2); BOMBICK B.(1)
    (1) RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.; (2) Covance Laboratories Ltd, Harrogate, North Yorkshire, U.K.
    The development of whole smoke/aerosol exposure systems provides a means to conduct in vitro assessment of freshly generated whole smoke and aerosol from combustible and tobacco heating products (THP) as well as electronic nicotine delivery systems (ENDS) ...