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99 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 27

    Next generation product aerosol bubbled extracts show little to no effect in high content screening endpoints when compared to cigarette smoke bubbled extracts

    TRELLES STICKEN E.(1); WIECZOREK R.(1); BODE L.M.(1); SIMMS L.(2); STEVENSON M.(2)
    (1) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), BioToxLab, Hamburg, Germany; (2) Imperial Tobacco Limited, In vitro Research, Bristol, U.K.
    Tobacco-based and tobacco-free next generation products (NGPs) are understood to be a less harmful alternative to conventional combustible cigarettes. The objective of this study was to compare the in vitro biological response of cigarette smoke and a ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 34

    Next generation product aerosols induce lower biological activity than combusted cigarettes: a comparison of in vitro cell migration in the scratch wound assay

    RUDD K.(1); BUDDE J.(2); TRELLES STICKEN E.(2); WIECZOREK R.(2); SIMMS L.(1); STEVENSON M.(1)
    (1) Imperial Brands PLC, Bristol, U.K.; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany
    Smoking combustible cigarettes is a cause of serious diseases in smokers, including heart disease. There are many commercially available next generation products (NGPs), such as tobacco-free e-vapour products, aiming to provide an alternative to smoking ...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 37

    Use of cell media nicotine concentration as a marker to predict cells surface deposited nicotine in transwells after fresh smoke/aerosol exposure

    WIECZOREK R.(1); TRELLES STICKEN E.(1); BODE L.M.(1); SIMMS l.(2)
    (1) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany; (2) Imperial Tobacco Limited, Bristol, U.K.
    Exposure of organotypic 3D lung models at the air liquid interface (ALI) to fresh whole smoke/aerosol provides a more human relevant exposure assessment of combustible cigarettes and e-vapour products. The aim of this study is to present a method for ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STW 01

    The application of in vitro Toxicity Testing in 21 Century (TT21C) for next generation products

    SIMMS L.(1); TRELLES STICKEN E.(2)
    (1) Imperial Brands PLC, Bristol, U.K.; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany
    The aim is to demonstrate the feasibility of TT21C in vitro methods as part of an overall assessment framework for next generation products (NGP). TT21C methodologies can be used to assess harm reduction potential of NGPs using human-derived cellular ...
  5. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 021

    Influence of the time of and stirring rate during the first step of synthesis of SBA-15 on its catalytic effect for reducing toxicants concentration in tobacco smoke

    JUÁREZ-SERRANO N.; ASENSIO-MORANT J.; MARTÍNEZ-CASTELLANOS I.; BERENGUER D.; BLASCO I.; BELTRÁN M.I.; MARCILLA A.
    University of Alicante, Alicante, Spain
    Certain mesoporous materials can modify notably the composition of smoke tobacco, since they can act as catalysts and/or adsorbents allowing to reduce the toxic and carcinogenic compounds of the smoke. However, the properties of the catalysts strongly ...
  6. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 023

    Effect of SBA-15 morphology in the composition of the mainstream tobacco smoke

    MARTÍNEZ-CASTELLANOS I.; MARCILLA A.; BELTRÁN M.I.; BERENGUER D.; BLASCO I.; JUAREZ N.; ASENSIO J.; CALABUIG E.
    University of Alicante, Alicante, Spain
    Mesoporous silica materials, such as SBA-15, are attracting increasing interest in the last years. Our research group has focused in their capability for reducing the toxic compounds generated in the smoking process when mixed with tobacco. By tuning the ...
  7. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 005

    Effect of the addition of SBA-15 in the pyrolysis of a reference tobacco under inert and oxidizing atmosphere

    CALABUIG E.; MARCILLA A.; BELTRÁN M.I.
    University of Alicante, San Vicente del Raspeig, Spain
    The composition of evolved products from slow pyrolysis under inert and oxidizing atmospheres of a reference tobacco 3R4F from the Reference Cigarette Program of the College of Agriculture of the University of Kentucky and a mixture of the reference ...
  8. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 034

    Influence of the time of synthesis of SBA-15 on its effect as a catalyst reducing toxicant concentration in tobacco smoke

    JUÁREZ-SERRANO N.; MARCILLA A.; BELTRÁN M.I.
    University of Alicante, San Vicente del Raspeig, Spain
    In recent years, SBA-15 has been suggested as an additive for reduction of toxic compounds in tobacco smoke. The structure of this type of materials is strongly dependent on the synthesis conditions. The objective of the present work is to analyze the ...