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4 results

  1. TSRC, Tob. Sci. Res. Conf., 2010, 64, abstr. 51

    Chronic cigarette smoke exposure induces vascular dysfunction through upregulation of cytoglobin in mouse aorta

    EL-MAHDY M.A.; EL-SHERBINY G.A.; ABDELGHANY T.M.; ZWEIER J.L.
    Ohio State University, Center for Environmental and Smoking Induced Diseases, Davis Heart and Lung Research Inst., Columbus, OH, USA
    Cigarette smoking is a risk factor for cardiovascular disease. The relationship between smoking and cardiovascular disease results from multiple mechanisms that interact to contribute to several pathological conditions, including vascular dysfunction. In ...
  2. TSRC, Tob. Sci. Res. Conf., 2010, 64, abstr. 52

    Chronic cigarette smoke exposure impairs vascular endothelial function through a tetrahydrobiopterin-dependent mechanism

    ABDELGHANY T.M.; EL-SHERBINY G.A.; EL-MAHDY M.A.; ZWEIER J.L.
    Ohio State University, Center for Environmental and Smoking Induced Diseases, Davis Heart and Lung Research Institute, Columbus, OH, USA
    Cigarette smoke exposure (CSE) is one of the major risk factors of cardiovascular disease. Although tobacco smoking is associated with the onset of atherosclerosis, coronary disease, and ischemic heart disease, the precise mechanism by which these ...
  3. TSRC, Tob. Sci. Res. Conf., 2009, 63, abstr. 19

    Development of in-vivo mouse model for smoking-induced cardiovascular disease

    EL-MAHDY M.A.; JOHNSON W.; HEMANN C.
    Ohio State University, Center for Environmental and Smoking Induced Diseases, Davis Heart and Lung Research Inst., Columbus, OH, USA
    Animal models for cigarette smoke associated diseases are important for research studies of the mechanisms involved in disease pathogenesis. We have developed an exposure protocol that results in cardiovascular dysfunction in the exposed mice. Male C57BL ...
  4. TSRC, Tob. Sci. Res. Conf., 2009, 63, abstr. 61

    Proteomicanalysis of biomarkers for smoking induced diseases in a mouse model

    TEWARI A.K.; EL-MAHDY M.A.; ZWEIER J.L.
    Ohio State University, Center for Environmental and Smoking Induced Diseases, Davis Heart and Lung Research Inst., Columbus, OH, USA
    Cigarette smoke (CS) exposure is considered a major risk factor for cardiovascular and pulmonary diseases. CS exposure leads to an increase in oxidative stress and inflammatory injury. In the current study, we have performed measurements and proteomic ...