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3 results

  1. TSRC, Tob. Sci. Res. Conf., 2013, 67, abstr. 19

    Tobacco product preparations differentially regulate human PBMC functions, including T cell and NK function.

    ARIMILLI S.(1); DAMRATOSKI B.E.(1); PRASAD G.L.(2)
    (1) Wake Forest University School of Medicine, Winston-Salem, NC, USA; (2) Reynolds Tobacco Company, Winston-Salem, NC, USA
    Natural Killer (NK) cells and T cells play essential roles in innate and adaptive immune responses in protecting against microbial infections and in tumor surveillance. Although evidence suggests that smoking causes immunosuppression, there is limited ...
  2. TSRC, Tob. Sci. Res. Conf., 2013, 67, abstr. 28

    The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces mitochondrial and nuclear DNA damage in Caenorhabditis elegans.

    PRASAD G.L.(1); BODHICHARLA R.(2); MEYER J.N.(2).
    (1) R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA; (2) Duke University, Durham, NC, USA
    The metabolites of the tobacco-specific nitrosamine NNK form DNA adducts in animal models. A previous report indicates that NNK could cause damage to the mitochondrial as well as nuclear genome in rats (Stepanov and Hecht, 2009 Chem. Res. Toxicol. 22: 406 ...
  3. TSRC, Tob. Sci. Res. Conf., 2013, 67, abstr. 31

    Biomarkers of tobacco effect: leukocyte subtypes as potential markers of inflammation in chronic tobacco consumers.

    PRASAD G.L.(1); ARIMILLI S.(2); CHEN P.(1); JONES B.A.(1)
    (1) R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA; (2) Wake Forest University School of Medicine, Winston-Salem, NC, USA
    Existing epidemiological data indicate that harm from smokeless tobacco consumption is significantly reduced compared to smoking, with no-tobacco-use being the least risky. Chronic cigarette smoking has been associated with increased inflammation and ...