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17 results

  1. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 05 (also presented at TSRC 2018)

    Structure-activity relationships of propylene glycol, glycerin, and select analogs for carbonyl thermal degradation products

    MELVIN M.S.; BALLENTINE R.M.; GARDNER W.P.; McKINNEY W.J.; PITHAWALLA Y.B.; SMITH D.C.; WAGNER K.A.
    Altria Client Services LLC, Richmond, VA, U.S.A.
    In 2016, the Food and Drug Administration (FDA) issued draft Guidance to Industry regarding the submission of Premarket Tobacco Applications for electronic nicotine delivery systems (ENDS). In this draft guidance, the FDA recommends reporting several ...
  2. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 07 (also presented at TSRC 2018)

    Evaluation of the formaldehyde hemiacetals and acetals relevant to electronic cigarettes

    JIN Xiaohong C.; AVERY K.C.; BALLENTINE R.M.; GARDNER W.P.; McKINNEY W.J.; MELVIN M.S.; PITHAWALLA Y.B.; SMITH D.C.; WAGNER K.A.
    Altria Client Services LLC, Richmond, VA, U.S.A.
    In 2016, the Food and Drug Administration (FDA) issued draft Guidance to Industry regarding the submission of Premarket Tobacco Applications for Electronic Nicotine Delivery Systems (ENDS). In this draft guidance, the FDA recommends reporting toxicants in ...
  3. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 29 (also presented at TSRC 2018)

    Toxicological assessment of e-liquid formulations using in vitro genotoxicity and cytotoxicity assays

    COFFA B.G.; DOSHI U.; ZHANG J.; McKINNEY W.J.; LEE K.M.
    Altria Client Services LLC, Richmond, VA, U.S.A.
    In the electronic nicotine delivery systems (ENDS) Premarket Tobacco Application (PMTA; 2016) Draft Guidance, the U.S. Food and Drug Administration (FDA) recommends a full assessment of the toxicological profile associated with new tobacco products, using ...
  4. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 30

    Effects of exposure to e-cigarette aerosols compared with cigarette smoke on 3D human buccal and small airway cultures: a systems toxicology assessment

    ISKANDER A.(1); STEINER S.(1); MAJEED S.(1); KONDYLIS A.(1); XIANG Yang(1); ZANETTI F.(1); FRENTZEL S.(1); MARTIN F.(1); PEITSCH M.C.(1); DOSHI U.(2); McKINNEY W.J.(2); LEE K.M.(2); HOENG J.(1)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) Altria Client Services LLC, Research, Development & Regulatory Affairs, Richmond VA, U.S.A.
    Considerable attention has been given toward the reduced risk potential of e-cigarettes (e-cigs). Most in vitro studies have focused on testing e-liquid formulations directly on submerged 2D cultures. Here, we examined the effects of exposure to the whole ...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 61

    A 6-month inhalation study in Apoe-/- mice to investigate cardiovascular and respiratory exposure effects of e-vapor aerosols compared with cigarette smoke

    WONG Ee Tsin(1); SZOSTAK J.(2); KRISHNAN S.(1); TAN Wei Teck(1); SEOW E.(1); TENG C.(1); LEE K.M.(3); ZHANG Jingjie(3); McKINNEY W.J.(3); PEITSCH M.C.(2); VANSCHEEUWIJCK P.(2); HOENG J.(2)
    (1) Philip Morris International Research Laboratories Pte. Ltd., (part of Philip Morris International group of companies), PMI R&D, Singapore; (2) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (3) Altria Client Services LLC, Richmond, VA, U.S.A.
    Chronic exposure to cigarette smoke is a risk factor for the development and progression of cardiovascular disease and chronic obstructive pulmonary disease. Considerable attention has been given towards the potential reduced harm of e cigarettes (e cigs) ...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 63 (also presented at TSRC 2018)

    Challenges and opportunities in cigar science

    SMITH J.H.(1); AUBUCHON S.M.(1); WAGNER K.A.(1); McKINNEY W.J.(1); GILLMAN I.G.(2); STEVENS R.(3)
    (1) Altria Client Services LLC, Richmond, VA, U.S.A.; (2) Enthalpy Analytical, Inc., Henrico, VA, U.S.A.; (3) ITG Brands LLC, Greensboro, NC, U.S.A.
    An independent Cigar Working Group has been formed by interested cigar stakeholders (e.g. manufacturers and testing laboratories). The goals of the Working Group are to explore opportunities for engagement with the Food and Drug Administration (FDA) on ...
  7. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 009 (also presented at CORESTA 2018)

    Toxicological assessment of e-liquid formulations using in vitro genotoxicity and cytotoxicity assays

    COFFA B.G.; DOSHI U.; ZHANG Jingjie; McKINNEY W.J.; LEE K.M.
    Altria Client Services LLC, Richmond, VA, USA
    In the Electronic Nicotine Delivery Systems (ENDS) Premarket Tobacco Application (PMTA; 2016) Draft Guidance, the FDA recommends a full assessment of the toxicological profile associated with new tobacco products, using in vitro toxicology (e.g., ...
  8. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 054 (also presented at CORESTA 2018)

    Challenges and opportunities in cigar science

    SMITH J.H.(1); AUBUCHON S.M.(1); WAGNER K.A.(1); McKINNEY W.J.(1); GILLMAN I.G.(2); STEVENS R.(3)
    (1) Altria Client Services LLC, Richmond, VA, USA; (2) Enthalpy Analytical, Henrico, VA, USA; (3) ITG Brands LLC, Greensboro, NC, USA
    An independent Cigar Working Group was formed by interested cigar stakeholders (e.g. manufacturers and testing laboratories). The goals of the Working Group are to explore opportunities for engagement with the Food and Drug Administration (“FDA”) on ...
  9. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 084 (also presented at CORESTA 2018)

    Evaluation of the formaldehyde hemiacetals and acetals relevant to electronic cigarettes

    JIN Xiaohong Cathy; AVERY K.C.; BALLENTINE R.M.; GARDNER W.P.; McKINNEY W.J.; MELVIN M.S.; PITHAWALLA Y.B.; SMITH D.C.; WAGNER K.A.
    Altria Client Services LLC, Richmond, VA, USA
    In 2016, the Food and Drug Administration (FDA) issued draft Guidance to Industry regarding the submission of Premarket Tobacco Applications for Electronic Nicotine Delivery Systems (ENDS). In this draft guidance, the FDA recommends reporting toxicants in ...