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14 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 13

    Importance of e-liquid preparation and stability characterization for a combinatorial safety assessment approach of flavors in e-liquids

    GLABASNIA A.(1); DIANA P.(1); SMITH C.(2); MILLER J.H.(2); BIASIOLI M.(1); FRAUENDORFER F.(1); SCIUSCIO D.(1); MARTIN E.(1); POSPISIL P.(1); GUY P.(1); VANSCHEEUWIJCK P.(1); HOENG J.(1); KUMAR A.(2); LEE K.M.(2)
    (1) PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (2) Altria Client Services LLC, Richmond, VA, U.S.A.
    Numerous flavorings are generally recognized as safe for use in food, but there is limited information available to evaluate their potential toxicity by inhalation. Consequently, gaining information on individual flavor safety levels is of...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 50 (also presented at TSRC 2019)

    In vitro dissolution testing of nicotine release from smokeless tobacco products

    MILLER J.H.; DANIELSON T.L.; ALDEEK F.; PITHAWALLA Y.B.; WILKINSON C.T.; BROWN A.P.; WAGNER K.A.
    Altria Client Services LLC, Richmond, VA 23219, U.S.A.
    Developing dissolution testing methods to measure the nicotine release profiles from smokeless tobacco products is valuable for product assessment and for product-to-product comparisons. Furthermore, it can allow for understanding which physical or...
  3. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 038

    Optimization and comparison of 2,4-dinitrophenylhydrazine (DNPH) derivatization conditions for the determination of carbonyl compounds

    JEONG L.(1); MILLER, J.H., IV(2); SHAH N.(2)
    (1) Eurofins Lancaster Laboratories, Richmond, VA, USA; (2) Altria Client Services, Richmond, VA, USA
    FDA’s Premarket Tobacco Product Application (PMTA) draft guidance for Electronic Nicotine Delivery Systems (ENDS) recommends analysis of four carbonyls in e-liquids and aerosols - Formaldehyde, Acetaldehyde, Acrolein and Crotonaldhyde. There are two...
  4. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 106

    Preclinical testing of flavors in e-vapor products - Part 4: Flavor transfer from the liquid to the aerosol for inhalation exposure

    ZHANG Jingjie; SMITH C.; ANDERSON C.; McCUTCHEON N.; MILLER J.H.; LEE K.M.
    Altria Client Services, Richmond, VA, USA
    Many flavor compounds used in e-liquids are generally recognized as safe (GRAS) for oral consumption. However, the respiratory effects of flavors in e-vapor aerosols are unknown. Preclinical inhalation studies can provide toxicity data to assess the...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 28 (also presented at TSRC 2018)

    Non-targeted analysis for differential screening of tobacco samples

    MILLER J.H.; PITHAWALLA Y.B.; DANIELSON T.L.; XU Dongmei
    Altria Client Services LLC, Richmond, VA, U.S.A.
    Non-targeted analysis of samples has broad applications across the food industry and in the evaluation of natural products. For example, this approach has been used by the food industry to evaluate purity and quality of fruit juices, olive oil and...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 44 (also presented at TSRC 2018)

    Non-targeted analysis using gas chromatography mass spectrometry to evaluate stability of e-vapor products

    SHAH N.; CROSSWHITE M.; NOE M.R.; SUAREZ C.; MILLER J.H.; PITHAWALLA Y.B.; GARDNER W.P.
    Altria Client Services LLC, Richmond, VA, U.S.A.
    In the newly regulated landscape of tobacco products there is an increasing need to fully characterize the chemical composition of aerosol in new products. Although aerosol from e-vapor products are considerably less complex than aerosols from...
  7. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 094

    Are available test methods for the determination of ammonia in mainstream cigarette smoke fit for the analysis of cigars? – Part 2

    PREPELITSKAYA Y.; MILLER J.H.; RUSYNIAK M.; HIGGINS F.S.; AVERY K.C.; CROSSWHITE M.; SPICER-GLAVE S.; SHAH N.
    Altria Client Services LLC, Richmond, VA, USA
    In May 2016, the U.S. Food and Drug Administration (FDA) issued a final rule deeming cigar products within scope of their regulatory authority. Under this regulation the FDA will require manufacturers to report the quantities of Harmful and...
  8. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 124 (also presented at CORESTA SSPT2017)

    Are available test methods for the determination of ammonia in mainstream cigarette smoke fit for the analysis of cigars?

    PREPELITSKAYA Y.; SPANGLER K.; SMITH J.H.; AVERY K.C.; WILKINSON J.; MELVIN M.S.; MILLER J.H.
    Altria Client Services, Richmond, VA, USA
    In May 2016, the U.S. Food and Drug Administration (FDA) issued a final rule to deem cigars to be subject to the Federal Food, Drug, and Cosmetic Act, as amended by the Family Smoking Prevention and Tobacco Control Act. As part of this regulation,...
  9. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 28

    Puffing profile effects on carbonyl formation in e-cigarette aerosols

    MILLER J.H.; FLORA J.W.; WILKINSON J.; WILKINSON C.; SINK K.M.; GARDNER W.P.; KARLES G.
    Altria Client Services LLC, Richmond, VA, U.S.A.
    It has been previously reported that aerosols from e-cigarettes can contain carbonyls such as formaldehyde, acetaldehyde, acrolein, and crotonaldehyde due to elevated temperatures of the heating coils. There have been several publications about...
  10. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 38 (also presented at TSRC 2016)

    Nicotine related impurities in e-cigarette cartridges and refill formulations

    FLORA J.W.; WILKINSON C.; SINK K.M.; McKINNEY D.L.; MILLER J.H.
    Altria Client Services LLC, Richmond, VA, U.S.A.
    The nicotine used in e-cigarette formulations is extracted from tobacco, and the purity of the nicotine can vary depending upon manufacturer and grade. The U.S. and European Pharmacopeias make recommendations for the purity of nicotine intended for...