Search Results

183 results

  1. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 17

    The dos and don’ts of non-targeted screening by LC–HRAM-MS for chemical characterization of smoke-free products

    WACHSMUTH C.; ARNDT D.; BUCHHOLZ C.; BENTLEY M.; GOUJON-GINGLINGER C.
    Philip Morris Products S.A., PMI R&D, Neuchâtel, Switzerland
    Liquid chromatography coupled to high-resolution accurate-mass spectrometry (LC–HRAM-MS)-based non-targeted screening (NTS) is a key methodology for characterizing the chemical composition of complex matrices. It enables simultaneous identification...
  2. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 18

    Computer-assisted structure identification (CASI) for high-throughput identification of small molecules by GC×GC–HRAM-TOFMS

    KNORR A.; ALMSTETTER M.; MARTIN E.; CASTELLON A.; POSPISIL P.; BENTLEY M.; GOUJON C.
    Philip Morris Products S.A., PMI R&D, Neuchâtel, Switzerland
    Compound identification is widely recognized as a major bottleneck in modern metabolomic approaches and high-throughput non-targeted characterization of complex matrices. An automated platform CASI (computer-assisted structure identification) was...
  3. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 19

    Non-targeted chemical characterization of complex matrices by nominal- and high-resolution accurate-mass GC×GC–TOFMS

    ALMSTETTER M.; KNORR A.; RHOUMA M.; MARTIN E.; CASTELLON A.; POSPISIL P.; BENTLEY M.; GOUJON C.
    Philip Morris Products S.A., PMI R&D, Neuchâtel, Switzerland
    Comprehensive chemical characterization is an important element in the development of heat-not-burn products. Beyond the challenge of developing powerful analytical methods with sufficient chromatographic and spectral resolution, it is essential to...
  4. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 21

    Untargeted chemical characterization of the aerosol generated by a heated tobacco product

    BENTLEY M.; ALMSTETTER M.; ARNDT D.; KNORR A.; MARTIN E.; POSPISIL P.; MAEDER S.
    Philip Morris Products S.A., PMI R&D, Neuchâtel, Switzerland
    In contrast to quantitative analysis, where chemical constituents of interest are targeted to the exclusion of all others, an untargeted approach considers indiscriminate determination of all analytes relevant to a specific chemical space. A...
  5. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 24

    Dos and don’ts in the design of indoor air quality studies on smoke-free products

    MITOVA M.I.; GOUJON-GINGLINGER C.; GOMEZ LUESO M.; ROTACH M.; MAEDER S.
    Philip Morris Products S.A., PMI R&D, Neuchâtel, Switzerland
    Indoor air quality (IAQ) studies on smoke-free products (SFPs), such as electrically heated tobacco products (EHTPs) and e-vapour products (EVPs), have demonstrated substantial reduction of environmental emissions relative to cigarette smoking. IAQ...
  6. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 25

    Human abuse liability assessment of tobacco and nicotine products: considerations to meet current regulatory recommendations

    BAXTER S.(1); VANSICKEL A.(2); SHERWOOD N.(3); CAMPBELL L.(1); KONG M.(4)
    (1) RAI Services Company, Winston Salem, NC, U.S.A.; (2) Altria Client Services, Richmond, VA, U.S.A.; (3) Neil Sherwood Consulting, Nyon, Switzerland; (4) Altasciences Clinical Research, Laval, QC, Canada
    The U.S. Food and Drug Administration (FDA) recommends that tobacco product manufacturers provide information regarding the abuse liability of tobacco and nicotine-containing products to support pre-market tobacco, modified risk tobacco product and...
  7. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 26

    Comparative risk assessment of heated tobacco product and electronic cigarette aerosols with cigarette smoke based on cancer potency and margin of exposure

    RODRIGO G.; JACCARD G.; TAFIN DJOKO D.; KORNELIOU A.; ESPOSITO M.; BELUSHKIN M.
    Philip Morris Products S.A., PMI R&D, Neuchâtel, Switzerland
    An average reduction of more than 90 % in concentrations of harmful and potentially harmful constituents (HPHCs; among given lists) has been observed in the aerosols of commercial heated tobacco products (HTPs) and electronic cigarettes (ECs)...
  8. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 27

    Cardiovascular, carcinogenic and reproductive effects of nicotine exposure: a narrative review of the scientific literature

    MARTINEZ J.; PRICE L.
    JT International SA, Geneva, Switzerland
    The emergence of new tobacco heating products and electronic nicotine delivery systems (ENDS) is changing the way humans are exposed to nicotine. The purpose of this narrative review is to provide a broad overview of published scientific literature...
  9. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, STPOST 05

    A screening method by gas chromatography–mass spectrometry for the quantitation of 33 aerosol constituents from a heat-not-burn tobacco product

    HOFER I.; GAUTIER L.; CORTES SAUTEUR E.; DOBLER M.; PYTHON A.; O’REILLY C.; GISI D.; TINGUELY E.; WEHREN L.; GARCÍA FIDALGO E.; CUKURCAM L.; HENNEMANN M.; MATERA R.; ROTA D.; SANTOS CH.; SEQUEIRA C.; EPARS T.
    Philip Morris Products S.A., PMI R&D, Neuchatel, Switzerland
    This screening method allows the quantitation of 33 compounds [phenol, o-cresol, m-cresol, p-cresol, catechol, resorcinol, hydroquinone, 1,3-butadiene, isoprene, benzene, acrylonitrile, toluene, pyridine, styrene, propylene glycol, menthol,...
  10. CORESTA Meeting, Agronomy/Phytopathology, 2019, Victoria Falls, AP 37

    Metabolic and transcriptomic shifts during tobacco leaf post-harvest senescence

    BOVET L.; HILFIKER A.; BATTEY J.; SIERRO N.; GOEPFERT S.
    PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    Tobacco is harvested after plant flowering, when the leaf senescence is more or less visible depending on cultivars. Before the drying phase, current practices allow the senescence to proceed until the detached leaf becomes yellow. This yellowing...