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  1. CORESTA Meeting, Agronomy/Phytopathology, 2021, Online, AP 34

    Dynamics of molecular leaf senescence processes occurring during curing of Virginia tobacco cultivar K326

    CHEVAL C.; BATTEY J.; SIERRO N.; DULIZE R.; BORNAND D.; SIMICEVIC J.; TITZ B.; GUY P.A.; LASZLO C.; HAIDUC A.; DOSSIN E.; BOVET L.; IVANOV N.; GOEPFERT S.
    Philip Morris International R&D, Philip Morris Products SA, Neuchâtel, Switzerland
    Plant senescence is the process of aging. It is influenced primarily by genetics and developmental processes as well as environmental cues. However, because of their significant complexity, the molecular networks by which genetics and the environment...
  2. CORESTA Meeting, Agronomy/Phytopathology, 2021, Online, AP 49

    Consequences of molecular genetic alteration of leaf nitrate levels on TSNAs, alkaloids, flowering time, and biomass in Burley tobaccos

    DEWEY R.E.(1); BOVET L.(2); GOEPFERT S.(2); CAMPANONI P.(2); LEWIS R.S.(1)
    (1) North Carolina State University, Dept. of Crop and Soil Sciences, Raleigh, NC, U.S.A.; (2) PMI R&D, Philip Morris Products S.A., Neuchatel, Switzerland
    We have previously demonstrated that tobacco-specific nitrosamine (TSNA) levels in Burley tobaccos can be substantially lowered using two distinct molecular genetic techniques designed to impede the plant’s ability to store high levels of free...
  3. CORESTA Meeting, Agronomy/Phytopathology, 2019, Victoria Falls, AP 37

    Metabolic and transcriptomic shifts during tobacco leaf post-harvest senescence

    BOVET L.; HILFIKER A.; BATTEY J.; SIERRO N.; GOEPFERT S.
    PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    Tobacco is harvested after plant flowering, when the leaf senescence is more or less visible depending on cultivars. Before the drying phase, current practices allow the senescence to proceed until the detached leaf becomes yellow. This yellowing...
  4. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, AP 24

    Downregulation of a putative nitrate transporter gene substantially reduces the accumulation of TSNAs in air-cured tobaccos

    GOEPFERT S.(1); BOVET L.(1); LU J.(2); CAMPANONI P.(1); LEWIS R.S.(2); DEWEY R.E.(2)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) North Carolina State University, Department of Crop Science, Raleigh, NC, U.S.A.
    Air-cured Burley tobacco leaves typically exhibit high levels of nicotine-derived nitrosamine ketone (NNK) and N'-nitrosonornicotine (NNN). It has been previously demonstrated that leaf nitrate accumulation in air-cured tobaccos serves as the source...
  5. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 070

    Genetic approaches and resources for enabling compliance to proposed NNN standards

    DEWEY R.E.(1); LEWIS R.S.(1); LU Jianli(1); BOVET L.(2); GOEPFERT S.(2); CAMPANONI P.(2)
    (1) North Carolina State University, Raleigh, NC, USA; (2) Philip Morris International, Neuchatel, Switzerland
    Tobacco-specific nitrosamines (TSNAs) are formed through the nitrosation of tobacco alkaloids. Over the past decade, we have demonstrated how altering the genetics of the tobacco plant can result in dramatic reductions in TSNA formation. This has...
  6. CORESTA Congress, Berlin, 2016, Agronomy/Phytopathology Groups, AP 22

    Nicotiana genomes: beyond tobacco

    SIERRO N.S.; BATTEY J.N.D.; OUADI S.; THOMAS J.; LIEDSCHULTE V.; BOVET L.; BROYE H.; LAPARRA H.; VUARNOZ A.; LANG G.; GOEPFERT S.; PEITSCH M.C.; IVANOV N.V.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    While Nicotiana tabacum is likely the most notable species from the Nicotiana genus, various other Nicotiana species are cultivated as crops, grown as ornamental garden plants, or used as model organisms in research. Within Solanaceae, Nicotiana...
  7. CORESTA Meeting, Agronomy/Phytopathology, 2015, Izmir, Turkey, APW 02

    The tobacco genome sequence

    SIERRO N.; BATTEY J.N.D.; OUADI S.; BAKAHER N.; BOVET L.; WILLIG A.; GOEPFERT S.; PEITSCH M.C.; IVANOV N.V.
    Philip Morris Products S.A., PMI R&D, Neuchâtel, Switzerland
    Nicotiana tabacum (common tobacco) is a major crop species and a model organism, for which only very fragmented genomic sequences have been available until recently. The three most commonly used tobacco types are flue-cured (or Virginia), Burley and...